An update on pathogenesis of inflammatory disorders with its management

Abstract

Objectives Pathogenesis of inflammation has been linked to a variety of diseases, so exploring the cause of inflammation is very much crucial. Once the cause is predicted then the treatment of the inflammation and related disorders become predictable. Key findings An inflammatory response is the immune system's response to harmful stimuli that can be triggered by pathogens, damaged cells, and toxic compounds. Inflammation and the diseases associated with it are becoming more popular. There are several complications that arise due to inflammation, such as cardiovascular disease, rheumatoid arthritis, gout, asthma, etc. Inflammation results in plethora of events characterised by release of inflammatory cytokines activation of nuclear factor kappa-B, mitogen-activated protein kinase, Janus kinase signalling, and the activator of transcription (signal transducer and activator of transcription) pathway, facilitate the process of inflammation. Hence with this review, it will open the vista for new interventions used in the management of inflammatory disorders. Summary This review deals with the various inflammatory disorder and pathogenesis associated with them. This article opens a window to explore more relevant pharmacological treatment for the benefit of the society. Till date the medication that is available for the management of in-flammatory diseases/disorders provides only symptomatic treatment and that is only to a limit. The medication such as steroids posses a serious adverse drug reactions and other option like disease modifying anti-rheumatic drugs/slow-acting anti-rheumatic drugs are not economical or budget friendly. Hence, with this review we can look for various targets that are beneficial in the management of inflammatory-related disorders.