C-src structure in human cancers with elevated pp60c-src activity1

Abstract

We used RNAase protection and restriction fragment length polymorphism assays to detect activating mutations of c-src in a spectrum of human tumours. No mutations were detected at codons 98, 381, 444, and 530. We conclude that mutational activation is not the mechanism of enhancement of ppWc-src specific kinase activity found in a number of human cancer types. © 1991 Macmillan Press Ltd.