Maternal HIV infection influences the microbiome of HIV-uninfected infants

Abstract

More than 1million HIV-exposed, uninfected infants are born annually to HIV-positive mothersworldwide. This growing population of infants experiences twice the mortality of HIV-unexposed infants.Wefound that although there were very few differences seen in themicrobiomes ofmothers with and without HIV infection, maternal HIV infection was associated with changes in the microbiome of HIV-exposed, uninfected infants. Furthermore, we observed that human breast milk oligosaccharides were associated with bacterial species in the infant microbiome. The disruption of the infant's microbiome associated with maternal HIV infection may contribute to the increased morbidity and mortality of HIV-exposed, uninfected infants.