Estimation of serum malondialdehyde before and after radiotherapy in oral squamous cell carcinoma patients undergoing antioxidant therapy

Abstract

Many researchers have shown that lipid peroxides (Malondialdehyde) are the by-products of the chemical damage done by-oxygen free radicals (ROS), to the lipid components of cell membrane, which showed changes in its serum values in radiation treated malignant cases and antioxidants mediate anticancer activity, by modifying the cellular metabolic balance. Present study was conducted with the aim to estimate and compare the serum malondialdehyde (MDA) level in normal individuals, oral cancer patients before and after radiotherapy undergoing antioxidant therapy.