Synthesis and antimicrobial activity of spiro-oxindole-chromene derivative compounds based curcuminoid and chalcone

Abstract

Multicomponent reactions (MCRs) are an efficient strategy to synthesize various heterocyclic compounds in one pot, and a simple step by combining the reactants in the same flask. In this study, a series of spiro-oxindole substituted chromene rings were synthesized via Knoevenagel and Micheal addition reaction using curcuminoid and chalcone as precursors. The reaction was assisted by Nickel ferrite (NiFe2O4) nanocatalyst in ethanol solvent at 70°C. NiFe2O4 was synthesized by the co-precipitation method and characterized by FTIR, XRD, and SEM-EDX. The two spiro-oxindole-chromene derivatives synthesized with the NiFe2O4 nanocatalyst were characterized their functional group vibrations and molecular mass by FTIR and GCMS, respectively. Under conditions with the addition of 5% (w/w) catalyst, the yields of compound 1 and compound 2 were 95% and 90%. Only compound 2 responded to antibacterial activity test against gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis).