Clonogenic cells in acute myeloblastic leukemia

Abstract

These clonogenic leukemic cells have been the subject of considerable investigation, and also the source of some controversy, in the ensuing years. The possibility that these clonogenic cells act as stem cells in vivo to maintain the rest of the leukemic cell population is an intriguing possibility that has potentially important therapeutic significance. The identification, culture, growth characteristics, and biological and clinical significance of clonogenic cells in AML will be the subject of this review.