Protective Effect of Ginger Extract against Cisplatin-Induced Nephrotoxicity in Rats

Abstract

This study was designed to evaluate the nephro protective effect of Ginger extract promoted by cisplatin. Animals were divided into7 groups as follow: Group1 (Control): Animals were injected intraperitoneal with1ml single saline dose. Group2 (DMSO): Animals were administered orally with1ml of 6.5% DMSO for 19 days. Group3 (cisplatin): Animals were injected intra peritoneal with cisplatin (10 mg/kg) as single dose. Group4 (Gingeronly): Animals were administrated orally with 600 mg/Kg/day of ginger extract for 19 days. Group 5, 6and7: Animals pretreated with oral dose of ginger extract (200, 400 and 600 mg /kg/day respectively) for 2 weeks before and 5 days after single IP cisplatin (10 g/kg). Administration cisplatin caused significant elevation in serum urea, creatinine concentration and kidney tissue levels of MDA and NO. Also caused significant increase in Caspase-3 levels, cisplatin significantly decreased level of Na. it decreased K, Mg and Ca level but statistically non-significant. Also it significantly decreased the antioxidant level of Catalase. Treatment with ginger extract restored the levels of kidney functions also oxidative stress markers and also decrease Caspase-3 level. Histopathological analysis confirmed that. ginger extract have a protective role in cisplatin induced nephrotoxicity.