Metabolo-epigenetic interplay provides targeted nutritional interventions in chronic diseases and ageing

Abstract

Metabolic and epigenetic imbalances result in disease. There are several factors that can cause an epigenetic imbalance and consequently different diseases. Some of these factors are intrinsic including genetic variations such as Single Nucleotide Polymorphism (SNPs) or DNA mutations caused by carcinogens and Reactive Oxygen Species (ROS); environmental factors including metabolic alterations such as obesity or ageing and lifestyle (unbalanced diet or sedentary lifestyle). This epigenetic imbalance leads to cardiovascular, neurological and cancer diseases. (Figure presented.)