How to use the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) in orthodontic research

Abstract

Introduction: Clinical trial protocols are essential documents that serve as a basis for research planning. The Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) statement aimed to increase the transparency and integrity of clinical trial protocols. Objectives: This paper described the main aspects of the SPIRIT, highlighting the importance of using this guideline in Ortho-dontics. Results: The SPIRIT is composed of 33 items and the diagram, which were presented and explained. Conclusion: The use of the SPIRIT checklist must become essential to increase the transparency and integrity of more reli-able and less biased clinical trials in orthodontic research, im-proving the quality of future publications in this field.