Acute toxicity study of DL-8280, a new synthetic antibacterial agent, in mice, rats, dogs and monkeys

Abstract

The acute toxicity of DL-8280, a new synthetic antibacterial agents, was investigated in mice, rats, dogs, and monkeys. LD50 values (mg/kg) of DL-8280 were as follows: p.o., 5,450 (male) and 5,290 (female) for mice, 3,590 (male) and 3,750 (female) for rats, >200 for dogs and 500∼1,000 for monkeys; s.c., > 10,000 (male and female) for mice and 7,070 (male) and 9,000 (female) for rats; i.V., 208 (male) and 233 (female) for mice, 273 (male) and 276 (female) for rats and >70 for dogs. Toxic signs after oral or subcutaneous administration included hypoactivity, ptosis, hypo-pnea, convulsion and tremor, and those after intravenous administration were collapse, convulsion and dyspnea, irrespective of the animal species. As an additional sign, emesis was frequently observed in dogs and monkeys. Pathological changes related to medication were congestion of the lung in most animals that died and enlargement of the cecum in some survivors of mice and rats receiving oral or subcutaneous administration. © 1984, Japanese Society of Chemotherapy. All rights reserved.