Synthesis, antimicrobial, antioxidant and docking study of novel isoxazoline derivatives

Abstract

A novel series of isoxazoline derivatives (3-10) was synthesized and characterized by using spectral analysis. The synthesized derivatives were in vitro screened against several bacterial species as well as Candida albicans and exhibit moderate to potent activity. All the synthesized products were screened qualitatively for their antioxidant property by using TLC technique and the percent DPPH radical scavenging activity of the potent derivatives (4-6,8) were evaluated. Docking study of isoxazoline derivatives 7 and 8 against L-Glutamine: D-fructose-6-phosphate amidotransferase (glucosamine-6-phosphate synthase), the target enzyme in antimicrobial chemotherapy, was evaluated to explore the interactions of the synthesized hits inside the amino acid residues of the enzyme active site. The docking outcomes strongly supported the in vitro assay of new derivatives against several microbial species.