Spectrophotometric Determination of Paracetamol Using Diazotization Coupling Reaction

  • Alubaidy G
  • Basheer A
  • Saied S
  • et al.
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Abstract

For the determination of metoclopramide hydrochloride (MCPD) in pharmaceutical formulations, a rapid and straightforward spectrophotometric method has been proposed. The method involves diazotizing the main amino group of MCPD with sodium nitrite followed by coupling reaction with reagent 1,7-Dihydroxynaphthalene (1,7-DHN) to form a stable and colored compound in alkaline medium of sodium hydroxide which showed a maximum absorbance intensity at the wavelength 578 nm. The linearity of developed method has ranged from 1.0 - 15 µg.ml-1 while the molar absorptivity 2.9867x104 l.mol-1.cm-1, RSD% was less than 1.11%. While the LOD and LOQ were 0.059 µg.ml-1 and 0.198 µg.ml-1 respectively. The method is appropriate for the determination of MCPD in the presence of other substances that are typically included in dosage forms.

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Alubaidy, G. F., Basheer, A. A., Saied, S. M., & Thanoon, E. S. (2019). Spectrophotometric Determination of Paracetamol Using Diazotization Coupling Reaction. Rafidain Journal of Science, 28(2), 76–83. https://doi.org/10.33899/rjs.2019.159979

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