For the determination of metoclopramide hydrochloride (MCPD) in pharmaceutical formulations, a rapid and straightforward spectrophotometric method has been proposed. The method involves diazotizing the main amino group of MCPD with sodium nitrite followed by coupling reaction with reagent 1,7-Dihydroxynaphthalene (1,7-DHN) to form a stable and colored compound in alkaline medium of sodium hydroxide which showed a maximum absorbance intensity at the wavelength 578 nm. The linearity of developed method has ranged from 1.0 - 15 µg.ml-1 while the molar absorptivity 2.9867x104 l.mol-1.cm-1, RSD% was less than 1.11%. While the LOD and LOQ were 0.059 µg.ml-1 and 0.198 µg.ml-1 respectively. The method is appropriate for the determination of MCPD in the presence of other substances that are typically included in dosage forms.
CITATION STYLE
Alubaidy, G. F., Basheer, A. A., Saied, S. M., & Thanoon, E. S. (2019). Spectrophotometric Determination of Paracetamol Using Diazotization Coupling Reaction. Rafidain Journal of Science, 28(2), 76–83. https://doi.org/10.33899/rjs.2019.159979
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