Synthesis, Characterization and Antimicrobial Activities of Silver Nanoparticles coated [1,3] Thiazin-4-One derivatives

Abstract

Heterocyclic compounds have been used extensively used in pharmaceutical research area due to their effective biological activities. Thiazine, a heterocyclic compound with four carbon atoms, one nitrogen and one sulfur atoms which have promising pharmacological activities that have attracted the attention of scientists and researchers. In this research [3-(4-Amino-phenyl)-2-(4-nitro-phenyl)-2,3-dihydro-benzo[e][1,3]thiazin-4-one [comp. (2)] was used as a synthone for the preparation of Schiff bases [comp.(3)-(7)]. The synthesis compounds were characterized by FT-IR, 1H NMR and spectrophotometric methods. Furthermore, silver nanoparticles was prepared by chemical reduction and characterized by X-Ray diffraction (XRD), infra-red spectrum (FTIR), atomic force microscope (AFM) and scanning electron microscope (SEM). The Ag NPs was used as a base nano metal for preparing Schiff bases-Ag NPs derivatives. The pure Ag NPs and Ag NPs functionalized Schiff bases nano compounds were used to check their effectiveness against four different types of bacterial (Staphylococcus aurous, Staphylococcus epidermidis, Escherichia coli and Klebsiella sp.) and one type of fungal (Candida albicans) by a serial dilution method.