Association between metabolic syndrome, radiographic knee osteoarthritis, and intensity of knee pain: Results of a national survey

Abstract

Context: Although osteoarthritis (OA) has been suggested as another component of metabolic syndrome (MetS), weight-independent associations between MetS and knee OA or intensity of arthritic knee pain remain unclear. Copyright Objective: The objective of the study was to evaluate the above associations and suggest possible mechanisms. Design and Setting: This was a cross-sectional study using the fifth Korean National Health and Nutrition Examination Survey (2010). Participants: A total of 2363 adults (≥50 y of age) who had completed both laboratory examinations and an evaluation for radiographic knee OA participated in the study. Main Outcome and Measures: Radiographic knee OA was defined as a Kellgren/Lawrence grade of 2 or greater, and the intensity of arthritic knee pain was assessed using a self-reported numeric rating scale. MetS was diagnosed based on National Cholesterol Education Program-Adult Treatment Panel III criteria, and insulin resistance was evaluated using the homeostasis model assessment- estimated insulin resistance index. Results: In a multivariable logistic regression analysis, MetS was associated with radiographic knee OA(adjusted odds ratio 1.49;95%confidence interval 1.23-1.79; P