Search for antibody catalysts for the ene reaction

Abstract

The design, computational studies and synthesis of transition state analogs for an ene reaction are described. The most promising analogs were used to elicit antibodies that should catalyze an ene reaction between maleimide and 1-decene. Preliminary results indicate that successful catalytic antibodies for the ene reaction can be produced in this manner. In parallel, an antibody library is being developed for the same purpose.