Tailoring the cell: a glimpse of how plant viruses manipulate their hosts

Abstract

Viruses are intracellular parasites that completely rely on the molecular machinery of the infected host to complete their cycle. Upon invasion of a susceptible cell, viruses dramatically reshape the intracellular environment to suit their needs, in a complex process that requires the fine manipulation of multiple aspects of the host cell biology, including those enabling replication of the viral genome, facilitating suppression or avoidance of anti-viral plant defence mechanisms, and supporting precise intra-cellular and inter-cellular trafficking of viral components. This tailoring of the cell to fit viral functions occurs through the coordinated action of fast-evolving, multifunctional viral proteins, which efficiently target host factors. In this review, we intend to offer a glimpse of how plant viruses manipulate their hosts from a cell biology perspective, focusing on recent advances covering three specific aspects of the viral infection: viral manipulation of organelle function; virus-induced formation of viral replication complexes through membrane remodelling; and viral evasion of autophagy.