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Atavistic strategy for the treatment of hyperuricemia via ionizable liposomal mRNA

Nature Communications (2024) 15(1)
DOI: 10.1038/s41467-024-50752-9
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Abstract

Urate oxidase (Uox) lost its function during evolution. Here the authors propose an atavistic strategy to treat hyperuricemia by using a proprietary lipid nanoparticle to load Uox mRNA, which reduced the serum uric acid levels effectively in two animal models.

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Zhang, M., Hussain, A., Hu, B., Yang, H., Li, C., Guo, S., … Huang, Y. (2024). Atavistic strategy for the treatment of hyperuricemia via ionizable liposomal mRNA. Nature Communications , 15(1). https://doi.org/10.1038/s41467-024-50752-9

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