Prostate Specific Membrane Antigen as Biomarker and Therapeutic Target for Prostate Cancer

Abstract

The Prostate Specific Membrane Antigen (PSMA) is considered to be the most well established target antigen in prostate cancer, since it is highly and specifically expressed at all tumor stages on the surface of prostate tumor cells. This chapter outlines the structure, function, and expression of PSMA, its relevance as prognostic and diagnostic biomarker, and different therapeutic approaches targeting this antigen.