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A Genetic Toggle for Chemical Control of Individual Plk1 Substrates

Cell Chemical Biology (2020) 27(3) 350-362.e8
DOI: 10.1016/j.chembiol.2020.01.007
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Abstract

Temporal and reversible control of individual phosphorylation events is essential for a complete understanding of kinase signaling in cellular processes. Here, a chemical-genetic approach, applicable to serine-threonine kinases, achieves such control over single substrates and uncovers novel properties of Plk1 signaling through Kif2b in mitosis.

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Johnson, J. M., Hebert, A. S., Drane, Q. H., Lera, R. F., Wan, J., Weaver, B. A., … Burkard, M. E. (2020). A Genetic Toggle for Chemical Control of Individual Plk1 Substrates. Cell Chemical Biology, 27(3), 350-362.e8. https://doi.org/10.1016/j.chembiol.2020.01.007

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