Ninth Australasian Gene and Cell Therapy Society Meeting

Abstract

The proceedings contain 66 papers. The topics discussed include: discovery of ancient and contemporary adeno-associated viruses from Australian marsupials; development of synthetic DNA reference material for accurate analysis of gene therapy vectors; targeted delivery of a synthetic microRNA mimic as an approach to cancer treatment; RNA-targeting promoter region inhibits activation of latently infected HIV-1; limiting thymic precursor supply increases the risk of lymphoid malignancy in SCID-XI mice: implications for gene therapy protocols targeting the haematopoietic compartment; genetically modified tumour cells expressing IL-15 and IL-15Ralpha as an in situ cancer vaccination platform; coherence analysis discriminates between retroviral integration patterns in CD34+ cells transduced under differing clinical trial conditions; melligen CELSS: an insulinsecreting human liver cell line which is resistant to cytokine-induced immune attack; temozolomide versus mgmt: trialling a gene therapy strategy to overcome drug resistance in the treatment of brain tomours; regeneratinghair cells in the cochlea using ATOH1 gene therapy; a phase 1 gene therapy trial with subretinal RAAV.SFLT-1 for the long-term treatment of wet agerelated macular degeneration: 1-year follow-up; and developing novel therapies and biomarkers for Friedreich ataxia.