Synthesis and antimicrobial evaluation of some new oxadiazoles derived from phenylpropionohydrazides

Abstract

In this study a series of new 1-(2-aryl-5-phenethyl-1,3,4-oxadiazol-3(2H)- yl)ethanones 2a-e was synthesized by the cyclization of imines la-e using acetic anhydride. The products were evaluated for anti-bacterial and anti-fungal activity. Among the newly synthesized compounds, 1-(2-(4-(dimethylamino)phenyl)- 5-phenethyl-1,3,4-oxadiazol-3(2H)-yl)ethanone (2a) and 1 -(2-(4-chlowphenyl)-5- phenethyl-1,3,4-oxadiazol-3(2H)-yl)ethanone (2b) were found to possess maximum activity against the tested strains of S. aureus and P. aeruginosa. It was concluded that para-substitution enhances the activity of synthesized oxadiazoles.