Development of 166Ho-phytate complex for Radiosynovectomy

Abstract

Background 66Ho-chloride was obtained by bombardment of natural Ho(NO3)3 dissolved in acidic media using thermal neutron flux (4-5×1013 n.cm-2.s-1). Methods 166Ho-holmium chloride (185 MBq) was used successfully for preparation of 166Ho-phytate complex with high radiochemical purity (>99.9 %, ITLC, MeOH: H2O: acetic acid, 4: 4: 2, as mobile phase). The complex stability and viscosity were checked in the final solution up to 2 days. The prepared complex solution (60 μCi/100 μl) was injected intraarticularly to male rat knee joints. Leakage of radioactivity from the injection site and its distribution in organs were investigated up to 2 days. Results Approximately all of the injected dose had remained in the injection site 2 days after injection. Conclusion The complex was proved to be a feasible agent for cavital radiotherapy in oncology and rheumatology. © Korean Society of Nuclear Medicine 2011.