Synthesis and biological evaluation of 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acids against Vaccínia virus

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Abstract

Several new 3-phenyl and 3-alkyl-1H-pyrazolo[3,4-b]pyridine derivatives (3a-e) were prepared and evaluated against Vaccinia virus on BSC-40 cells. The derivatives 3a, 3b and 3d showed an inhibitory activity above 90% at 30 μM, 40 μM and 50 μM concentrations.

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Azevedo, A. R., Ferreira, V. F., De Mello, H., Leão-Ferreira, L. R., Jabor, A. V., Frugulhetti, I. C. P. P., … Bernardino, A. M. R. (2002). Synthesis and biological evaluation of 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acids against Vaccínia virus. Heterocyclic Communications, 8(5), 427–432. https://doi.org/10.1515/HC.2002.8.5.427

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