Abstract
An improved tool to explore the origin of human immunoglobulin heavy chains, named Ab-origin, has been developed. It can analyze in detail the V-D-J joints from the rearranged sequence by searching against germline databases. In addition to the known information about antibody recombination, appropriate score system and restriction of searching location are also incorporated to improve computing performance. When compared with a newly developed software SoDA, Ab-origin performed much better in both accuracy and stability, with 2, 7 and 1 percent higher for V, D and J respectively. Though only taking the human heavy chain for an example here, the algorithm also suits for the analysis of all immunoglobulin and TCR sequences. © Springer-Verlag Berlin Heidelberg 2007.
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Wang, X., Wei, W., Zheng, S. Y., Cao, Z. W., & Li, Y. (2007). Ab-origin: An improved tool of heavy chain rearrangement analysis for human immunoglobulin. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 4488 LNCS, pp. 363–369). Springer Verlag. https://doi.org/10.1007/978-3-540-72586-2_52
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