Geographic and seasonal variation in malaria prevalence on islands in Lake Victoria (western Kenya): results from three cross sectional studies

Abstract

Background Kenya launched its second National Malaria Strategy with a notably ambitious vision for a “malaria free Kenya”, but malaria remains a major health problem among communities in Lake Victoria in western Kenya. Materials and methods We conducted three cross-sectional surveys during the dry (January 2012) and two consecutive wet seasons (August 2012 and August 2013) among communities residing in three different settings in Lake Victoria: (1) along the mainland coast (Ungoye: population ∼2,000); (2) on a large island (Mfangano: population ∼25,000); and (3) on small islands (Takawiri, Kibuogi, and Ngodhe: population ∼700 each). The prevalence of malaria infections and G6PD deficiency was analyzed by geography and/or season. Results Overall, parasite rates (PRs) as determined by microscopy (18.9% vs 18.4%), rapid diagnostic test (RDT; 36.9% vs 30.8%) and PCR (31.1% vs 28.5%) were higher in the dry season than in the wet seasons with characteristic age distribution. In both seasons, PRs were highest in the coast, then in the large island and lowest on the small islands. The highest prevalence by RDT during the dry season was observed in Ungoye: 54.4% in age group 0-5 years old, 68.4% in 6-10, 55.3% in 11- 15, 13.2% in 16-30 and 11.3% in >30. Species-specific prevalence by PCR was 29.3% for Plasmodium falciparum, 8.5% for P. malariae, and 2.1% for P. ovale in the dry season, and 26.6%, 7.2%, and 3.3%, respectively, in the wet seasons. Prevalence of mixed infections was 8.3% and 7.1% in the dry and wet seasons, respectively. P. vivax was not detected by microscopy or PCR in any survey. Significant seasonal fluctuations in PRs were observed among children and young adolescents on islands but not in the coast. Among all settings, G6PD deficiency was found in 12.1% of males and 2.1% of females. No significant correlation between G6PD deficiency rates and PRs was observed in any settings. Conclusions Variation in malaria prevalence reflects the different dynamic of malaria transmission between the islands and the coast of Lake Victoria. Our results provide baseline data for the planned feasibility study of malaria elimination on islands in Lake Victoria.