Enantioselective synthesis of α-amino esters through Petasis borono-Mannich multicomponent reaction of potassium trifluoroborate salts

Abstract

Enantioselective synthesis of α-amino esters have been achieved through the Petasis borono-Mannich multicomponent reaction using (R)-BINOL-derived catalysts with stable heteroaryl and alkenyl trifluoroborate salts under mild conditions. The reaction provides direct access to optically active α-amino esters with moderate to good yields and enantioselectivities.