Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody-drug conjugate (ADC)

João P.M. Nunes; Maurício Morais; Vessela Vassileva; Eifion Robinson; Vineeth S. Rajkumar; Mark E.B. Smith; R. Barbara Pedley; Stephen Caddick; James R. Baker; Vijay Chudasama

Journal ArticleOPEN ACCESS

Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody-drug conjugate (ADC)

Chemical Communications (2015) 51(53) 10624-10627

DOI: 10.1039/c5cc03557k

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Abstract

Herein we report the use of next generation maleimides (NGMs) for the construction of a potent antibody-drug conjugate (ADC) via functional disulfide bridging. The linker has excellent stability in blood serum and the ADC, armed with monomethyl auristatin E (MMAE), shows excellent potency and cancer cell selectivity in vitro. This journal is

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Nunes, J. P. M., Morais, M., Vassileva, V., Robinson, E., Rajkumar, V. S., Smith, M. E. B., … Chudasama, V. (2015). Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody-drug conjugate (ADC). Chemical Communications, 51(53), 10624–10627. https://doi.org/10.1039/c5cc03557k

Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody-drug conjugate (ADC)

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