The Correlation between p53 Serum Levels and Vascular Age was Measured by Carotid Intima Media Thickness (CIMT) in Patients with Moderate Cardiovascular Risk Factors

Abstract

Protein p53 has an important role in atherosclerosis plaque as part of senescence cell vascular. Increased vascular aging process is characterized by several parameters, one of which is an increase in carotid intima media thickness (CIMT). CIMT is one of the non-invasive methods that can determine vascular age, which is a safe, fast and inexpensive method of assessing atherosclerosis. This study was a correlational study conducted at cardiovascular outpatient clinic from August until November 2015. Serum p53 levels were measured by human p53 ELISA kit. CIMT is measured by B-mode ultrasound. The CIMT value was based on the normogram of the Atheosclerosis Risk in Communities Study. Spearman rank test was used to analyze the relationship between serum p53 and vascular age. There were 19 men and 19 women in the subject of this study. The average vascular age is 54.34 + 8.5 years. Serum p53 levels were positively correlated with vascular age in the subject group of this study (p <0.001; r = 0.58). There is a positive, strong and significant correlation between serum p53 and vascular age levels determined by CIMT in patients with moderate cardiovascular risk factors.