Directing CLL-cell traffic

Abstract

In this issue of Blood, Lafouresse et al visualized the in vivo behavior of human chronic lymphocytic leukemia (CLL) cells within the mouse lymph node (LN) microcirculation and discovered that CLL cells bind to LN high endothelial venules (HEVs) via an L-selectin (CD62L)-dependent adhesion process. They also found that CLL cells from patients treated with the B-cell receptor (BCR) inhibitor idelalisib decrease their levels of L-selectin and reduce binding to LN HEVs.