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APOBEC3 as a driver of genetic intratumor heterogeneity

Molecular and Cellular Oncology (2021) 10(1)
DOI: 10.1080/23723556.2021.2014734
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Abstract

Our recent study revealed that APOBEC3B is upregulated during the preinvasive stages of non-small cell lung cancer and breast cancer. In addition to its role in mediating single nucleotide variants, we propose that APOBEC3 promotes copy number intratumor heterogeneity prior to invasion, providing a substrate for cancer evolution.

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APA

Venkatesan, S., Angelova, M., Bartkova, J., Bakhoum, S. F., Bartek, J., Kanu, N., & Swanton, C. (2021). APOBEC3 as a driver of genetic intratumor heterogeneity. Molecular and Cellular Oncology, 10(1). https://doi.org/10.1080/23723556.2021.2014734

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