The Effectiveness Of Topical Avocado In The Treatment Of Minor Recurrent Aphthous Ulceration: A Randomized Controlled Clinical Trial

Abstract

Background: Recurrent aphthous ulceration (RAU) causes painful sores on the lips, cheeks, soft palate, tongue, throat and floor of the mouth. Different treatment modalities have been suggested to either eradicate or reduce the duration of ulcer recurrences but some of their clinical values remain controversial. Natural avocado oil is a novel potent herbal medicine that enhance wound healing through quenching reactive oxygen species, inhibiting inflammatory process and accelerating proliferating phase.Aim : The purpose of this research was to determine the effectiveness of topically applied 0.5% avocado gel in the treatment of (RAU) .Subjects and method : Sixty patients in the ulcerative stage of RAU were divided at random among two groups . Group I: Patients received topical 0.5% avocado gel three times daily for seven days. GroupII : Patients received topical placebo gel three times daily for seven days. The patients were examined at the time of initial visit before treatment administration and on the fourth and the seventh day of treatment .Results : The results showed that topical 0.5% avocado gel were more effective than placebo gel in the management of minor recurrent aphthous RAU ulceration as it reduces the pain after its application more than the placebo gel alone. Patients on 0.5% topical avocado gel therapy revealed less degree of erythema, decrease in ulcer size and healing period than patients on the placebo therapy .