Facile syntheses of Mannich bases of 3-[p-(5-arylpyrazolin-3-yl)phenyl] sydnones, as anti-tubercular and anti-microbial agents, under ionic liquid/tetrabutylammonium bromide catalytic conditions

Abstract

Novel methylene bridged Mannich bases 2a-j were synthesized in good to excellent yields from the pyrazoline derivative 1 using various primary/ secondary amines, 37 % formalin in presence of ionic liquids/TBAB as catalyst. The structures of the newly synthesized compounds were confirmed by IR, 1H- and 13C-NMR and GC-MS spectroscopy, as well as elemental analysis. The title compounds were screened for their anti-tubercular and antimicrobial activities. Some of the compounds exhibited very good anti-tubercular, antifungal and antibacterial activities.