Impact of global left ventricular afterload on left ventricular function in asymptomatic severe aortic stenosis: A two-dimensional speckle-tracking study

121Citations
Citations of this article
82Readers
Mendeley users who have this article in their library.

Abstract

Aims The present study sought to assess the effect of global left ventricular (LV) afterload on LV myocardial systolic function in patients with aortic stenosis (AS) and preserved LV ejection fraction. Methods and results We prospectively examined the LV myocardial deformation (i.e. longitudinal, radial, and circumferential) by two-dimensional speckle tracking in 173 patients with asymptomatic severe AS. Thirty-eight patients (22) had low flow as determined by a low stroke volume index (≤35 mL/m 2). By multivariable analysis, four variables emerged as independently associated with low-flow AS: peak Ea velocity (P = 0.01), left atrial area index (P = 0.017), global LV afterload (P = 0.024), and circumferential myocardial deformation (P = 0.04). Forty-nine patients (28) had an increased global LV afterload (≥5 mmHg mL/m 2). Systemic arterial compliance (P = 0.001), circumferential myocardial deformation (P = 0.024), and left atrial area index (P = 0.04) were independently associated with increased global LV load in multivariable analysis. Of note, LV ejection fraction was not identified as a determinant of low flow or increased afterload. Conclusion In asymptomatic patients with severe AS, LV ejection fraction markedly underestimates the extent of myocardial systolic impairment. Intrinsic myocardial dysfunction is particularly common in patients with increased global LV afterload, and especially in the subset of patients with low-flow AS. © The Author 2010.

Cite

CITATION STYLE

APA

Lancellotti, P., Donal, E., Magne, J., O’Connor, K., Moonen, M. L., Cosyns, B., & Pierard, L. A. (2010). Impact of global left ventricular afterload on left ventricular function in asymptomatic severe aortic stenosis: A two-dimensional speckle-tracking study. European Journal of Echocardiography, 11(6), 537–543. https://doi.org/10.1093/ejechocard/jeq014

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free