Two Dogs with Osteogenesis Imperfecta

Abstract

Two young dogs (a 4-month-old male French Bulldog, and a 4-month-old male Akita) presented with severe systemic pain involving bone resorption and multiple fractures. Other diseases characterized by bone fragility were excluded by clinical examinations, and so the dogs were provisionally diagnosed with osteogenesis imperfecta. In both dogs, the systemic pain resolved within 1 week after the start of diagnostic treatment with oral bisphosphonate (0.5-1.0 mg/kg), and bone unions were achieved in the multiple fractures. The two dogs have been in good physical condition without further fractures for 27 and 22 months, respectively. The definitive diagnosis of canine osteogenesis imperfecta is currently difficult because it requires genetic diagnosis. Diagnostic treatment with oral bisphosphonate is effective in alleviating potentially fatal symptoms in dogs with suspected osteogenesis imperfecta. 全身の骨吸収を伴う疼痛と多発性骨折を呈した犬の 2 症例（症例 1：フレンチブルドッグ 4 ヶ月齢、症例 2：秋田犬 4 ヶ 月齢）が来院した。鑑別診断を実施した上で両症例を骨形成不全症と診断し、ビスホスホネート製剤の投与を開始した（ボ ナロン錠 5 mg、帝人ファーマ、0.5-1.0 mg/kg） 。投与開始後、両症例とも 7 日以内に全身の疼痛は消失し、外科的および保 存的治療で良好な骨癒合が得られた。現時点で犬の骨形成不全症は診断および治療法が確立されていない。ゆえに、本疾患 が疑われる患者に対するビスホスホネート製剤の投与は、重度な症状の緩和と診断的治療に有効であることが示唆された。 ：骨形成不全症、多発性骨折、若齢犬 Jpn.