Efficient synthesis of 2,5-diketopiperazines by Staudinger-mediated cyclization

Abstract

Solution- and solid-phase Staudinger-mediated cyclizations were assessed to efficiently prepare hetero-2,5-diketopiperazines from their protected azido dipeptide thioesters under microwave irradiation. Short reaction time, good yields and ease of purification are the main assets of this methodology. © Georg Thieme Verlag Stuttgart · New York.