Inhibitory Effect of Liposome-Encapsulated Penicillin G on Growth of Listeria monocytogenes in Mouse Macrophages

Abstract

Administration of penicillin G encapsulated in liposomes inhibited the proliferation of Listeria which infected mouse intraperitoneal resident macrophages whereas free penicillin G and/or liposomes did not. This result suggests that administration of antibiotics encapsulated in liposomes is an effective treatment for the intracellular infection. © 1986, Tohoku University Medical Press. All rights reserved.