Tumor resistance

Abstract

It is suggested that evolution has equipped humans and other species with powerful and, largely non-immunological resistance mechanisms that can nip pre-neoplastic cells, as well as cells disseminating from established tumors in the bud. These mechanisms must operate while maintaining tissue structure, polarity and a large variety of cell-to-cell interactions. Altogether, they are essential for microenvironmental tissue integrity. It has further been postulated that the genes underpinning microenvironmental control are not merely alleles of known cancer susceptibility genes, but constitute sui generis systems. © 2012 Landes Bioscience.