The Multifunctional Therapeutic Approach to Treatment of Alzheimer’s Disease: Molecular Bases, Pharmacology and Perspectives in Medicinal Chemistry

Abstract

Alzheimer’s disease (AD) is a chronic neurodegenerative disease that affects a large part of the elderly population, aged over 65 years. With increasing life expectancy, AD has become the most common form of dementia, leading to progressive impairment of daily living activities and a variety of neuropsychiatric symptoms and behavioral changes. Despite advances in recent years, the chemotherapy treatment of AD still presents a challenge, since a great part of the therapies only act in the reduction of the symptoms in order to improve the quality of life of the patient. In this context, this mini review seeks to illustrate and emphasize the need to understand AD at a molecular level and to combine multi-target strategies in order to develop new drugs, safe use and with fewer adverse effects, as a way to contribute to the advancement of research in an area that represents a major global public health problem