HuR: Post-transcriptional paths to malignancy

Abstract

The RNA-binding protein HuR regulates the stability and translation of target mRNAs. While no HuR mutations have been found in cancer, a link between HuR and malignant transformation has been suggested in cancers of the breast, colon, lung, and ovary. We describe a paradigm consistent with a central role of HuR in oncogenesis. ©2005 Landes Bioscience.