High Prescription Rate of Medications with Rifampin Drug-drug Interactions in Patients with Diabetic Foot Osteomyelitis: Should Rifabutin Be Included in Clinical Trials for Adjunctive Therapy?

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Abstract

Rifampin may improve diabetic foot osteomyelitis outcomes, but its extensive drug-drug interactions could hamper its use. Here, through a review of the medications prescribed to a cohort of 190 persons with diabetic foot osteomyelitis, we show that rifabutin, a rifamycin with fewer drug-drug interactions, would be easier to implement in practice.

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Mallarino-Haeger, C., Watson, A., Mahgoub, U., Francis, L., Heydari, M., Choudhary, M., … Schechter, M. C. (2024). High Prescription Rate of Medications with Rifampin Drug-drug Interactions in Patients with Diabetic Foot Osteomyelitis: Should Rifabutin Be Included in Clinical Trials for Adjunctive Therapy? Open Forum Infectious Diseases, 11(11). https://doi.org/10.1093/ofid/ofae582

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