Microwave Irradiation Synthesis of Various Substituted Chalcones Using Various Heterogeneous Catalysts under Solvent - Free Conditions and their Biological Studies

Abstract

Synthesis of eight substituted chalcones using various heterogeneous catalysts such as Mont- K10, anhydrous K2CO3, anhydrous ZnCl2 and fused Ba(OH)2 under MWI was carried out to improved Claisen –Schmidt condensation reaction. A comparative aspect of different compounds in respect of different catalysts, time taken and per cent yield has been discussed. The advantages of this process is to design and develop new synthetic routes to various bioactive chalcone which is environmentally desirable and economically viable. The structures of all the compounds have been established by analytical and spectral (IR, 1H NMR, & mass) data. The synthesized compounds were also used for various biological screening