A Review: Formulation and Characterization of Fast Dissolving Tablet of Carvidilol

Abstract

Carvedilol a poorly water soluble drug undergoes extensive first pass metabolism, which reduces its bioavailability to 25-30%. Fast dissolving tablets of Carvedilol were prepared with the purpose of delivering the drug directly into the systemic circulation and bypassing the hepatic first pass metabolism with a concomitant increase in bioavailability. The solubility of Carvedilol was improved by forming inclusion complex with cyclodextrin which was then further used for the formulation of Fast dissolving tablet. Keywords: Carvedilol, Superdisintegrats, Fast dissolving Tablets and FDTs.