Synthesis of (-)-indolizidine 167B based on domino hydroformylation/ cyclization reactions

Abstract

Abstract. The synthesis of (-)-Indolizidine 167B has been achieved from optically active (R)-3-(pyrrol-1-yl)hex-1-ene. The key step is a highly regioselective hydroformylation reaction and a one-pot intramolecular cyclization providing a general approach to the indolizine nucleus. © 2008 Guazzelli et al; licensee Beilstein-Institut.