Effect of peroxisome proliferator-activated receptor-α agonist (bezafibrate) on gastric secretion and gastric cytoprotection in rats

Abstract

The effect of peroxisome proliferator-activated receptor-α (PPAR-α) on gastric secretion and gastric cytoprotection was evaluated using five different models of gastric ulcers: acetic acid-induced chronic gastric ulcers, pylorus ligation, ethanol-induced, indomethacin-induced and ischemia-reperfusion-induced gastric ulcers. Bezafibrate, a PPAR-α agonist was administered at two different doses of 10 and 100 mg/kg body weight intraperitoneanally. Both doses of bezafibrate showed significant antiulcer effect in ethanol-induced, indomethacin-induced and pylorus ligation-induced gastric ulcers. Bezafibrate increased healing of ulcer in acetic acid-induced chronic gastric ulcer model. Both doses were also effective in preventing gastric lesions induced by ischemia-reperfusion. It was concluded that PPAR-α activation increases healing of gastric ulcers and also prevents development of gastric ulcers in rats. © 2007 The Authors.