A macrophage-neutrophil program drives mammary carcinogenesis

Abstract

The molecular and cellular pathways through which breast cancer evades immunosurveillance remain poorly understood. Recent data from Camargo et al. demonstrate that – on recruitment to the tumor microenvironment by ductal macrophages – a heterogeneous population of neutrophils can establish physical contacts with malignant cells within spatial niches that sustain mammary oncogenesis.