A tale of metabolites: The cross-talk between chromatin and energy metabolism

Abstract

Mitochondrial metabolism infl uences histone and DNA modifications by retrograde signaling and activation of transcriptional programs. Considering the high number of putative sites for acetylation and methylation in chromatin, we propose in this perspective article that epigenetic modifications might impinge on cellular metabolism by affecting the pool of acetyl-CoA and S -adenosylmethionine. © 2013 American Association for Cancer Research.