An efficient synthesis of new benzo[1′,2′:6,7]quinolino[2,3-d]- pyrimidine derivatives via three-component microwave-assisted reaction

Abstract

(Chemical Equation Presented) A series of benzo[1′,2′:6,7] quinolino[2,3-d]pyrimidine derivatives were synthesized via condensation of an aromatic aldehyde, 2-hydroxy naphthalene-1,4-dione and 2,6-diaminopyrimidin-4- one in mixed solvent of acetic acid and glycol (3:1,V:V) under microwave irradiation. This one-pot protocol has the advantage of good yield (86-91%), simple workup procedure and rapid reaction time (4-8min).