Cytotoxic steroids from the stem barks of pandanus tectorius

Abstract

n-Hexane extract of the stem barks of Pandanus tectorius Parkins, ex J. P. du Roi collected in Thuathien-Hue province, Vietnam has shown a good cytotoxicity activity against KB (a human epidermal carcinoma) cell line with the IC50 value of 45.33 μg mL-1. Investigation on the chemical constituents of this extract has resulted in the isolation of four compounds: (a) Stigmast-4-en-3-one, (b) Stigmasta-4,22-dien-3-one, (c) Cycloeucalenol and (d) Stigmast-22-en-3β-ol. Their structures were determined by various spectroscopic methods. In addition, compounds (a-c) were evaluated their cytotoxic activity against KB cell line, compound b has moderate activity (IC50 value of 88.96 μg mL-1). ©2014 Academic Journals Inc.