Postprandial VLDL-triacylglycerol secretion is not suppressed in obese type 2 diabetic men

Abstract

Aims/hypothesis: Type 2 diabetes is characterised by insulin resistance and increased post-absorptive secretion of VLDL-triacylglycerol (VLDL-TAG). Whether postprandial suppression of endogenous VLDL-TAG secretion is abnormala finding that would link hyperlipidaemia and type 2 diabetesremains unclear. Methods: Eight type 2 diabetic men and eight healthy men were studied before and after a fat-free test meal (40% of resting energy expenditure). VLDL-TAG kinetics were assessed using a primed-constant infusion of ex vivo labelled [1- 14 C]triolein VLDL-TAG using non-steady-state calculations. Results: Type 2 diabetic men had a higher basal VLDL-TAG secretion rate and concentration than healthy men (mean∈±∈SD secretion rate 137∈±∈61 vs 78∈±∈30 μmol/min, respectively [p∈=∈0.03]; median concentration 1.03 [range 0.58-1.75] vs 0.33 [0.13-1.14]∈mmol/l, respectively [p∈