Comparative study on effect of Panax notoginseng and ticlid in treating early diabetic nephropathy

Abstract

OBJECTIVE: To explore the ameliorative effect and mechanism of Panax notoginseng (PNG) and ticlid in treating early diabetic nephropathy (DN). METHODS: Fifty-eight patients were divided randomly into two groups, 28 patients of the ticlid group treated with ticlid 250 mg orally, once a day and 30 patients of the PNG group treated with PNG 8 ml in 250 ml of normal saline intravenous drip once a day. The therapeutic effect and relative indexes of the two groups were observed and compared. RESULTS: After treatment, in both groups, the thromboxane B2 markedly reduced and was more prominent in the ticlid group (P < 0.05), while the 6-keto-prostaglandin F1 alpha increased obviously, so as to cause a significant lowering of T/K ratio, P < 0.01. Levels of urinary albumin, beta 2 microglobulin and blood alpha 1 microglobulin of both groups were lowered significantly, P < 0.01. A significant positive linear correlation was found in the ticlid group between urinary albumin and T/K ratio (r = 0.41, P < 0.01), as well as in blood alpha 1 microglobulin with T/K ratio (r = 0.34, P < 0.05), while it was not found in the PNG group. CONCLUSION: Ticlid and PNG were beneficial to resume the balance of T/K and improve microcirculation, reduce whole blood viscosity and decrease urinary albumin so as to retard the progress of DN.